7RQ8
Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.50A resolution
This is a non-PDB format compatible entry.
Summary for 7RQ8
Entry DOI | 10.2210/pdb7rq8/pdb |
Descriptor | 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (62 entities in total) |
Functional Keywords | iboxamycin, clindamycin, lincosamides, structure-based drug design, antibiotic, resistance, methylation, a2058, 23s rrna, 70s ribosome, inhibition of translation, peptidyl transferase center, nascent peptide exit tunnel, ribosome, ribosome-rna complex, ribosome/rna |
Biological source | Escherichia coli More |
Total number of polymer chains | 112 |
Total formula weight | 4566385.35 |
Authors | Mitcheltree, M.J.,Pisipati, A.,Syroegin, E.A.,Silvestre, K.J.,Klepacki, D.,Mason, J.D.,Terwilliger, D.W.,Testolin, G.,Pote, A.R.,Wu, K.J.Y.,Ladley, R.P.,Chatman, K.,Mankin, A.S.,Polikanov, Y.S.,Myers, A.G. (deposition date: 2021-08-06, release date: 2021-10-13, Last modification date: 2023-11-15) |
Primary citation | Mitcheltree, M.J.,Pisipati, A.,Syroegin, E.A.,Silvestre, K.J.,Klepacki, D.,Mason, J.D.,Terwilliger, D.W.,Testolin, G.,Pote, A.R.,Wu, K.J.Y.,Ladley, R.P.,Chatman, K.,Mankin, A.S.,Polikanov, Y.S.,Myers, A.G. A synthetic antibiotic class overcoming bacterial multidrug resistance. Nature, 599:507-512, 2021 Cited by PubMed: 34707295DOI: 10.1038/s41586-021-04045-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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