7RP2
Crystal structure of Kas G12C in complex with 2H11 CLAMP
Summary for 7RP2
Entry DOI | 10.2210/pdb7rp2/pdb |
Descriptor | GTPase KRas, immunoglobulin IgG heavy chain, immunoglobulin IgG light chain, ... (8 entities in total) |
Functional Keywords | gtpase, antibody, conformation-specific, hydrolase-immune system complex, hydrolase/immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 67005.19 |
Authors | |
Primary citation | Davies, C.W.,Oh, A.J.,Mroue, R.,Steffek, M.,Bruning, J.M.,Xiao, Y.,Feng, S.,Jayakar, S.,Chan, E.,Arumugam, V.,Uribe, S.C.,Drummond, J.,Frommlet, A.,Lu, C.,Franke, Y.,Merchant, M.,Koeppen, H.,Quinn, J.G.,Malhotra, S.,Do, S.,Gazzard, L.,Purkey, H.E.,Rudolph, J.,Mulvihill, M.M.,Koerber, J.T.,Wang, W.,Evangelista, M. Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors. Nat.Biotechnol., 40:769-778, 2022 Cited by PubMed: 34992247DOI: 10.1038/s41587-021-01126-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report