7RNW

SARS-CoV-2 Main Protease in complex with a cyclic peptide inhibitor

Summary for 7RNW

Entry DOI	10.2210/pdb7rnw/pdb
Descriptor	3C-like proteinase, ACE-DTY-LEU-GLN-TYR-ALA-VAL-LEU-ARG-HIS-LYS-ARG-ARG-GLU-SEC (3 entities in total)
Functional Keywords	protease, drug design, complex, covid-19, viral protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2) More
Total number of polymer chains	8
Total formula weight	142950.70
Authors	Frkic, R.L.,Jackson, C.J. (deposition date: 2021-07-30, release date: 2022-03-16, Last modification date: 2023-10-18)
Primary citation	Johansen-Leete, J.,Ullrich, S.,Fry, S.E.,Frkic, R.,Bedding, M.J.,Aggarwal, A.,Ashhurst, A.S.,Ekanayake, K.B.,Mahawaththa, M.C.,Sasi, V.M.,Luedtke, S.,Ford, D.J.,O'Donoghue, A.J.,Passioura, T.,Larance, M.,Otting, G.,Turville, S.,Jackson, C.J.,Nitsche, C.,Payne, R.J. Antiviral cyclic peptides targeting the main protease of SARS-CoV-2. Chem Sci, 13:3826-3836, 2022 Cited by PubMed: 35432913 DOI: 10.1039/d1sc06750h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation