7RMH

Substance P bound to active human neurokinin 1 receptor in complex with miniGs399

Summary for 7RMH

• Entry DOI: 10.2210/pdb7rmh/pdb
• EMDB information: 24570
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: substance p, g protein, gpcr, neurokinin, tachykinin, signaling protein, signaling protein-membrane protein complex, signaling protein/membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 141547.57

Authors

Harris, J.A.,Faust, B.,Gondin, A.B.,Daemgen, M.A.,Suomivuori, C.M.,Veldhuis, N.A.,Cheng, Y.,Dror, R.O.,Thal, D.,Manglik, A. (deposition date: 2021-07-27, release date: 2021-11-03, Last modification date: 2022-01-05)

• Primary citation: Harris, J.A.,Faust, B.,Gondin, A.B.,Damgen, M.A.,Suomivuori, C.M.,Veldhuis, N.A.,Cheng, Y.,Dror, R.O.,Thal, D.M.,Manglik, A.; Selective G protein signaling driven by substance P-neurokinin receptor dynamics.; Nat.Chem.Biol., 18:109-115, 2022; PubMed: 34711980; DOI: 10.1038/s41589-021-00890-8

Experimental method

ELECTRON MICROSCOPY (3.1 Å)