7RH2
IRF4 Transcription factor mutant -K59R
Summary for 7RH2
Entry DOI | 10.2210/pdb7rh2/pdb |
Descriptor | ICSAT transcription factor, DNA (5'-D(*CP*AP*AP*CP*TP*GP*AP*AP*AP*CP*CP*GP*AP*GP*AP*AP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*TP*TP*CP*TP*CP*GP*GP*TP*TP*TP*CP*AP*GP*TP*TP*G)-3'), ... (4 entities in total) |
Functional Keywords | irf4, cancer, homodimer complex, protein/dna interaction, transcription factor, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 75830.49 |
Authors | Williams, S.J.,Sundararaj, S.,Casarotto, M.G. (deposition date: 2021-07-16, release date: 2022-05-25, Last modification date: 2023-10-18) |
Primary citation | Sundararaj, S.,Seneviratne, S.,Williams, S.J.,Enders, A.,Casarotto, M.G. The molecular basis for the development of adult T-cell leukemia/lymphoma in patients with an IRF4 K59R mutation. Protein Sci., 31:787-796, 2022 Cited by PubMed: 34913532DOI: 10.1002/pro.4260 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.47 Å) |
Structure validation
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