7REW

Crystal Structure of IL-13 in complex with MMAb3 Fab

Summary for 7REW

• Entry DOI: 10.2210/pdb7rew/pdb
• Descriptor: anti-cyno interleukin 13 Fab heavy chain, anti-cyno interleukin 13 Fab light chain, IL13, ... (4 entities in total)
• Functional Keywords: alpha-helical bundle, protein-fab complex, cytokine
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 118296.46

Authors

Sudom, A.,Min, X. (deposition date: 2021-07-13, release date: 2022-05-25, Last modification date: 2023-10-18)

• Primary citation: Kielczewska, A.,D'Angelo, I.,Amador, M.S.,Wang, T.,Sudom, A.,Min, X.,Rathanaswami, P.,Pigott, C.,Foltz, I.N.; Development of a potent high-affinity human therapeutic antibody via novel application of recombination signal sequence-based affinity maturation.; J.Biol.Chem., 298:101533-101533, 2022; PubMed: 34973336; DOI: 10.1016/j.jbc.2021.101533

Experimental method

X-RAY DIFFRACTION (2.1 Å)