7REN
Room temperature serial crystal structure of Glutaminase C in complex with inhibitor UPGL-00004
Summary for 7REN
Entry DOI | 10.2210/pdb7ren/pdb |
Descriptor | Glutaminase kidney isoform, mitochondrial, 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide (3 entities in total) |
Functional Keywords | hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 238899.67 |
Authors | Milano, S.K.,Finke, A.,Cerione, R.A. (deposition date: 2021-07-13, release date: 2022-05-25, Last modification date: 2023-10-18) |
Primary citation | Milano, S.K.,Huang, Q.,Nguyen, T.T.,Ramachandran, S.,Finke, A.,Kriksunov, I.,Schuller, D.J.,Szebenyi, D.M.,Arenholz, E.,McDermott, L.A.,Sukumar, N.,Cerione, R.A.,Katt, W.P. New insights into the molecular mechanisms of glutaminase C inhibitors in cancer cells using serial room temperature crystallography. J.Biol.Chem., 298:101535-101535, 2022 Cited by PubMed: 34954143DOI: 10.1016/j.jbc.2021.101535 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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