7RDW

Crystal Structure of FH1 Fab bound to HXb2 HIV-1 gp120 core

Summary for 7RDW

• Entry DOI: 10.2210/pdb7rdw/pdb
• Descriptor: Glycoprotein 120, FH1 Fab Heavy Chain, FH1 Fab Light Chain, ... (10 entities in total)
• Functional Keywords: fh1, vh1-2*02, vrc01, antibody, hiv-1, immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 12
• Total formula weight: 365285.29

Authors

Weidle, C.,Pancera, M. (deposition date: 2021-07-12, release date: 2022-05-25, Last modification date: 2023-10-18)

• Primary citation: Gray, M.D.,Feng, J.,Weidle, C.E.,Cohen, K.W.,Ballweber-Fleming, L.,MacCamy, A.J.,Huynh, C.N.,Trichka, J.J.,Montefiori, D.,Ferrari, G.,Pancera, M.,McElrath, M.J.,Stamatatos, L.; Characterization of a vaccine-elicited human antibody with sequence homology to VRC01-class antibodies that binds the C1C2 gp120 domain.; Sci Adv, 8:eabm3948-eabm3948, 2022; PubMed: 35507661; DOI: 10.1126/sciadv.abm3948

Experimental method

X-RAY DIFFRACTION (3.55 Å)