7RCI

Crystal Structure of a PMS2 VUS with Substrate

Summary for 7RCI

Entry DOI	10.2210/pdb7rci/pdb
Descriptor	Mismatch repair endonuclease PMS2, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	mismatch repair, variant of uncertain significance, atpase domain, dna repair enzyme, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	82035.39
Authors	D'Arcy, B.M.,Prakash, A. (deposition date: 2021-07-07, release date: 2022-03-02, Last modification date: 2023-10-25)
Primary citation	D'Arcy, B.M.,Arrington, J.,Weisman, J.,McClellan, S.B.,Yang, Z.,Deivanayagam, C.,Blount, J.,Prakash, A. PMS2 variant results in loss of ATPase activity without compromising mismatch repair. Mol Genet Genomic Med, 10:e1908-e1908, 2022 Cited by PubMed: 35189042 DOI: 10.1002/mgg3.1908 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.12 Å)

Structure validation