7RBR

The crystal structure of Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with a Lys48-linked di-ubiquitin

Summary for 7RBR

Entry DOI	10.2210/pdb7rbr/pdb
Descriptor	Papain-like protease, Ubiquitin, ZINC ION, ... (6 entities in total)
Functional Keywords	covid-19, coronavirus, sars, cov-2, papain-like protease, ubiquitin, idp51000, idp52003, center for structural genomics of infectious diseases, csgid, hydrolase
Biological source	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) More
Total number of polymer chains	2
Total formula weight	44880.06
Authors	Osipiuk, J.,Tesar, C.,Endres, M.,Lanham, B.T.,Wydorski, P.,Fushman, D.,Joachimiak, L.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2021-07-06, release date: 2021-09-29, Last modification date: 2023-10-25)
Primary citation	Wydorski, P.M.,Osipiuk, J.,Lanham, B.T.,Tesar, C.,Endres, M.,Engle, E.,Jedrzejczak, R.,Mullapudi, V.,Michalska, K.,Fidelis, K.,Fushman, D.,Joachimiak, A.,Joachimiak, L.A. Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin. Nat Commun, 14:2366-2366, 2023 Cited by PubMed: 37185902 DOI: 10.1038/s41467-023-38031-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.88 Å)

Structure validation