7R74

Crystal structure of llama VHH antibody in complex with HIV-1 HXBC2 gp120 core

Summary for 7R74

Entry DOI	10.2210/pdb7r74/pdb
Related	3TMF
Descriptor	Glycoprotein 120, Antibody C8 VHH domain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	llama, antibody, vhh, hiv-1, gp120, immune system
Biological source	Human immunodeficiency virus 1 More
Total number of polymer chains	4
Total formula weight	109021.63
Authors	Zhou, T.,Kwong, P.D. (deposition date: 2021-06-24, release date: 2022-03-30, Last modification date: 2023-10-18)
Primary citation	Zhou, T.,Chen, L.,Gorman, J.,Wang, S.,Kwon, Y.D.,Lin, B.C.,Louder, M.K.,Rawi, R.,Stancofski, E.D.,Yang, Y.,Zhang, B.,Quigley, A.F.,McCoy, L.E.,Rutten, L.,Verrips, T.,Weiss, R.A.,Doria-Rose, N.A.,Shapiro, L.,Kwong, P.D. Structural basis for llama nanobody recognition and neutralization of HIV-1 at the CD4-binding site. Structure, 30:862-875.e4, 2022 Cited by PubMed: 35413243 DOI: 10.1016/j.str.2022.03.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.76 Å)

Structure validation