7R2V

Structure of nsp14 from SARS-CoV-2 in complex with SAH

Summary for 7R2V

Entry DOI	10.2210/pdb7r2v/pdb
Descriptor	Proofreading exoribonuclease nsp14, S-ADENOSYL-L-HOMOCYSTEINE, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
Functional Keywords	nsp14, complex, sah, sars-cov-2, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2
Total number of polymer chains	2
Total formula weight	120617.99
Authors	Czarna, A.,Plewka, J.,Kresik, L.,Matsuda, A.,Abdulkarim, K.,Robinson, C.,OByrne, S.,Cunningham, F.,Georgiou, I.,Pachota, M.,Popowicz, G.M.,Wyatt, P.G.,Dubin, G.,Pyrc, K. (deposition date: 2022-02-06, release date: 2022-03-09, Last modification date: 2024-01-31)
Primary citation	Czarna, A.,Plewka, J.,Kresik, L.,Matsuda, A.,Karim, A.,Robinson, C.,O'Byrne, S.,Cunningham, F.,Georgiou, I.,Wilk, P.,Pachota, M.,Popowicz, G.,Wyatt, P.G.,Dubin, G.,Pyrc, K. Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity. Structure, 30:1050-1054.e2, 2022 Cited by PubMed: 35609600 DOI: 10.1016/j.str.2022.04.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.53 Å)

Structure validation