7R1X

human Carbonic Anhydrase II in complex with 4-oxo-N-(4-sulfamoylphenethyl)-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline-2-carbothioamide

This is a non-PDB format compatible entry.

Summary for 7R1X

• Entry DOI: 10.2210/pdb7r1x/pdb
• Descriptor: Carbonic anhydrase 2, GLYCEROL, 4-oxo-N-(4-sulfamoylphenethyl)-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline-2-carbothioamide, ... (5 entities in total)
• Functional Keywords: sulfonamide, human carbonic anhydrase ii, inhibitor, metalloenzyme, lyase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 29891.14

Authors

Angeli, A.,Ferraroni, M. (deposition date: 2022-02-03, release date: 2023-02-15, Last modification date: 2024-02-07)

• Primary citation: Angeli, A.,Ferraroni, M.,Carta, F.,Haberli, C.,Keiser, J.,Costantino, G.,Supuran, C.T.; Development of Praziquantel sulphonamide derivatives as antischistosomal drugs.; J Enzyme Inhib Med Chem, 37:1479-1494, 2022; PubMed: 35635137; DOI: 10.1080/14756366.2022.2078970

Experimental method

X-RAY DIFFRACTION (1.35 Å)