7R04

Neurofibromin in open conformation

Summary for 7R04

Entry DOI	10.2210/pdb7r04/pdb
Related	7R03
EMDB information	14219
Descriptor	Isoform I of Neurofibromin, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE (2 entities in total)
Functional Keywords	signalling protein, homodimer, neurofibromatosis, gap, signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	635360.87
Authors	Chaker-Margot, M.,Scheffzek, K.,Maier, T. (deposition date: 2022-02-01, release date: 2022-03-30, Last modification date: 2022-04-20)
Primary citation	Chaker-Margot, M.,Werten, S.,Dunzendorfer-Matt, T.,Lechner, S.,Ruepp, A.,Scheffzek, K.,Maier, T. Structural basis of activation of the tumor suppressor protein neurofibromin. Mol.Cell, 82:1288-, 2022 Cited by PubMed: 35353986 DOI: 10.1016/j.molcel.2022.03.011 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.7 Å)

Structure validation