7QHW

TTBK1 kinase domain in complex with inhibitor 29

This is a non-PDB format compatible entry.

Summary for 7QHW

• Entry DOI: 10.2210/pdb7qhw/pdb
• Descriptor: Tau-tubulin kinase 1, ~{N}-[4-(4-chloranylphenoxy)phenyl]-7~{H}-pyrrolo[2,3-d]pyrimidin-4-amine, SULFATE ION, ... (5 entities in total)
• Functional Keywords: kinase, inhibitor, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 69264.79

Authors

Nozal, V.,Liehta, D. (deposition date: 2021-12-14, release date: 2022-10-26, Last modification date: 2024-01-31)

• Primary citation: Nozal, V.,Martinez-Gonzalez, L.,Gomez-Almeria, M.,Gonzalo-Consuegra, C.,Santana, P.,Chaikuad, A.,Perez-Cuevas, E.,Knapp, S.,Lietha, D.,Ramirez, D.,Petralla, S.,Monti, B.,Gil, C.,Martin-Requero, A.,Palomo, V.,de Lago, E.,Martinez, A.; TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.; J.Med.Chem., 65:1585-1607, 2022; PubMed: 34978799; DOI: 10.1021/acs.jmedchem.1c01942

Experimental method

X-RAY DIFFRACTION (2.8 Å)