7QGX

Human carbonic anhydrase II in complex with 3-((5-chloro-4-(4-chlorophenyl)thiazol-2-yl)(4-sulfamoylphenyl)amino)propanoic acid

Summary for 7QGX

• Entry DOI: 10.2210/pdb7qgx/pdb
• Descriptor: Carbonic anhydrase 2, ZINC ION, 3-[[5-chloranyl-4-(4-chlorophenyl)-1,3-thiazol-2-yl]-(4-sulfamoylphenyl)amino]propanoic acid, ... (5 entities in total)
• Functional Keywords: drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 29928.88

Authors

Paketuryte-Latve, V.,Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2021-12-10, release date: 2022-05-04, Last modification date: 2024-01-31)

• Primary citation: Balandis, B.,Simkunas, T.,Paketuryte-Latve, V.,Michailoviene, V.,Mickeviciute, A.,Manakova, E.,Grazulis, S.,Belyakov, S.,Kairys, V.,Mickevicius, V.,Zubriene, A.,Matulis, D.; Beta and Gamma Amino Acid-Substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases.; Pharmaceuticals, 15:-, 2022; PubMed: 35455474; DOI: 10.3390/ph15040477

Experimental method

X-RAY DIFFRACTION (1.19 Å)