7QB4

Mus Musculus Acetylcholinesterase in complex with 7-[(1-benzylpiperidin-3-yl)methoxy]-3,4-dimethyl-2H-chromen-2-one

Summary for 7QB4

• Entry DOI: 10.2210/pdb7qb4/pdb
• Descriptor: Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,4-dimethyl-7-[[1-(phenylmethyl)piperidin-4-yl]methoxy]chromen-2-one, ... (8 entities in total)
• Functional Keywords: inhibitor, complex, hydrolase
• Biological source: Mus musculus (House mouse)
• Total number of polymer chains: 2
• Total formula weight: 123440.57

Authors

Ekstrom, F.J.,Forsgren, N. (deposition date: 2021-11-18, release date: 2022-04-06, Last modification date: 2024-01-31)

• Primary citation: Ekstrom, F.,Gottinger, A.,Forsgren, N.,Catto, M.,Iacovino, L.G.,Pisani, L.,Binda, C.; Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures.; Acs Med.Chem.Lett., 13:499-506, 2022; PubMed: 35300078; DOI: 10.1021/acsmedchemlett.2c00001

Experimental method

X-RAY DIFFRACTION (2.50001104077 Å)