7PWZ

Crystal structure of 14-3-3 sigma in complex with a C-terminal Estrogen Receptoralpha phosphopeptide, stabilised by Pyrrolidone1 derivative 228

Summary for 7PWZ

• Entry DOI: 10.2210/pdb7pwz/pdb
• Related: 7PWT
• Descriptor: 14-3-3 protein sigma, C-terminus of Estrogen receptor alpha, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: nuclear receptor, phosphorylation, trafficking, ppi stabiliser, chaperone
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 27909.47

Authors

Andrei, S.A.,Bosica, F.,O'Mahony, G.,Ottmann, C. (deposition date: 2021-10-07, release date: 2022-12-21, Last modification date: 2024-01-31)

• Primary citation: Pallesen, J.S.,Munier, C.C.,Bosica, F.,Andrei, S.A.,Edman, K.,Gunnarsson, A.,La Sala, G.,Putra, O.D.,Srdanovic, S.,Wilson, A.J.,Wissler, L.,Ottmann, C.,Perry, M.W.D.,O'Mahony, G.; Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction.; J.Med.Chem., 65:16818-16828, 2022; PubMed: 36484727; DOI: 10.1021/acs.jmedchem.2c01635

Experimental method

X-RAY DIFFRACTION (2.5 Å)