7PVU

Crystal structure of p38alpha C162S in complex with CAS2094511-69-8, P 1 21 1

Summary for 7PVU

• Entry DOI: 10.2210/pdb7pvu/pdb
• Related: 7PV3 7Q1A
• Descriptor: Mitogen-activated protein kinase 14, N-(2-cyclobutyl-1H-1,3-benzodiazol-5-yl)-2-fluorobenzene-1-sulfonamide (3 entities in total)
• Functional Keywords: kinase, enzyme, inhibitor, ligand, oncoprotein
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 2
• Total formula weight: 82815.43

Authors

Baginski, B.,Pous, J.,Gonzalez, L.,Macias, M.J.,Nebreda, A.R. (deposition date: 2021-10-05, release date: 2023-05-17, Last modification date: 2024-02-07)

• Primary citation: Gonzalez, L.,Diaz, L.,Pous, J.,Baginski, B.,Duran-Corbera, A.,Scarpa, M.,Brun-Heath, I.,Igea, A.,Martin-Malpartida, P.,Ruiz, L.,Pallara, C.,Esguerra, M.,Colizzi, F.,Mayor-Ruiz, C.,Biondi, R.M.,Soliva, R.,Macias, M.J.,Orozco, M.,Nebreda, A.R.; Characterization of p38 alpha autophosphorylation inhibitors that target the non-canonical activation pathway.; Nat Commun, 14:3318-3318, 2023; PubMed: 37308482; DOI: 10.1038/s41467-023-39051-x

Experimental method

X-RAY DIFFRACTION (2.154 Å)