7PRX

wildtype ligand binding domain of the glucocorticoid receptor complexed with velsecorat and a PGC1a coactivator fragment

Summary for 7PRX

Entry DOI	10.2210/pdb7prx/pdb
Descriptor	Glucocorticoid receptor, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, Velsecorat, ... (4 entities in total)
Functional Keywords	nuclear receptor, ligand-activated transcription factor, agonist, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	31977.10
Authors	Edman, K.,Wissler, L.,Koehler, C.,Postel, S. (deposition date: 2021-09-22, release date: 2023-02-08, Last modification date: 2024-02-07)
Primary citation	Postel, S.,Wissler, L.,Johansson, C.A.,Gunnarsson, A.,Gordon, E.,Collins, B.,Castaldo, M.,Kohler, C.,Oling, D.,Johansson, P.,Froderberg Roth, L.,Beinsteiner, B.,Dainty, I.,Delaney, S.,Klaholz, B.P.,Billas, I.M.L.,Edman, K. Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication. Nat.Struct.Mol.Biol., 30:286-295, 2023 Cited by PubMed: 36747092 DOI: 10.1038/s41594-022-00914-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation