7PRV

The glucocorticoid receptor in complex with fluticasone furoate, a PGC1a coactivator fragment and sgk 23bp

Summary for 7PRV

• Entry DOI: 10.2210/pdb7prv/pdb
• Descriptor: Glucocorticoid receptor, DNA (5'-D(*TP*CP*GP*AP*CP*GP*GP*AP*CP*AP*AP*AP*AP*TP*GP*TP*TP*CP*TP*GP*TP*A)-3'), DNA (5'-D(*TP*AP*CP*AP*GP*AP*AP*CP*AP*TP*TP*TP*TP*GP*TP*CP*CP*GP*TP*CP*GP*A)-3'), ... (8 entities in total)
• Functional Keywords: nuclear receptor, ligand-activated transcription factor, multi-domain, complex, agonist, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 106889.65

Authors

Postel, S.,Edman, K.,Wissler, L. (deposition date: 2021-09-22, release date: 2023-02-08, Last modification date: 2024-02-07)

• Primary citation: Postel, S.,Wissler, L.,Johansson, C.A.,Gunnarsson, A.,Gordon, E.,Collins, B.,Castaldo, M.,Kohler, C.,Oling, D.,Johansson, P.,Froderberg Roth, L.,Beinsteiner, B.,Dainty, I.,Delaney, S.,Klaholz, B.P.,Billas, I.M.L.,Edman, K.; Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication.; Nat.Struct.Mol.Biol., 30:286-295, 2023; PubMed: 36747092; DOI: 10.1038/s41594-022-00914-4

Experimental method

X-RAY DIFFRACTION (2.7 Å)