7PPN

SHP2 catalytic domain in complex with CD28 (183-198) phosphopeptide (pTyr-191, p-Thr-195)

Summary for 7PPN

• Entry DOI: 10.2210/pdb7ppn/pdb
• Descriptor: Tyrosine-protein phosphatase non-receptor type 11,Tyrosine-protein phosphatase non-receptor type 11, T-cell-specific surface glycoprotein CD28, GLYCEROL, ... (4 entities in total)
• Functional Keywords: shp2, phosphatase, cd28, phosphopeptide, signaling, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 34920.34

Authors

Sok, P.,Zeke, A.,Remenyi, A. (deposition date: 2021-09-14, release date: 2022-09-07, Last modification date: 2024-01-31)

• Primary citation: Zeke, A.,Takacs, T.,Sok, P.,Nemeth, K.,Kirsch, K.,Egri, P.,Poti, A.L.,Bento, I.,Tusnady, G.E.,Remenyi, A.; Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling.; Nat Commun, 13:5439-5439, 2022; PubMed: 36114179; DOI: 10.1038/s41467-022-32918-5

Experimental method

X-RAY DIFFRACTION (1.9 Å)