7PP1
Crystal structure of the P2Y12 receptor in complex with the inverse agonist selatogrel.
This is a non-PDB format compatible entry.
Summary for 7PP1
| Entry DOI | 10.2210/pdb7pp1/pdb |
| Descriptor | P2Y purinoceptor 12,Soluble cytochrome b562,P2Y purinoceptor 12, Selatogrel, CHOLESTEROL, ... (4 entities in total) |
| Functional Keywords | inverse agonist, complex, membrane protein |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 1 |
| Total formula weight | 54254.15 |
| Authors | Mac Sweeney, A.,Tidten-Luksch, N. (deposition date: 2021-09-13, release date: 2022-11-02, Last modification date: 2024-01-31) |
| Primary citation | Pons, V.,Garcia, C.,Tidten-Luksch, N.,Mac Sweeney, A.,Caroff, E.,Gales, C.,Riederer, M.A. Inverse agonist efficacy of selatogrel blunts constitutive P2Y12 receptor signaling by inducing the inactive receptor conformation. Biochem Pharmacol, 206:115291-115291, 2022 Cited by PubMed: 36306820DOI: 10.1016/j.bcp.2022.115291 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.78 Å) |
Structure validation
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