7PGM

HHIP-C in complex with heparin

Summary for 7PGM

• Entry DOI: 10.2210/pdb7pgm/pdb
• Descriptor: Hedgehog-interacting protein, 2-O-sulfo-alpha-L-idopyranuronic acid-(1-3)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose (2 entities in total)
• Functional Keywords: hhip, hedgehog, morphogen, signalling, glycosaminoglycan, cholesterol, palmitate, secreted, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 3
• Total formula weight: 159841.40

Authors

Griffiths, S.C.,Schwab, R.A.,El Omari, K.,Bishop, B.,Iverson, E.J.,Malinuskas, T.,Dubey, R.,Qian, M.,Covey, D.F.,Gilbert, R.J.C.,Rohatgi, R.,Siebold, C. (deposition date: 2021-08-14, release date: 2021-12-15, Last modification date: 2024-01-31)

• Primary citation: Griffiths, S.C.,Schwab, R.A.,El Omari, K.,Bishop, B.,Iverson, E.J.,Malinauskas, T.,Dubey, R.,Qian, M.,Covey, D.F.,Gilbert, R.J.C.,Rohatgi, R.,Siebold, C.; Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling.; Nat Commun, 12:7171-7171, 2021; PubMed: 34887403; DOI: 10.1038/s41467-021-27475-2

Experimental method

X-RAY DIFFRACTION (2.7 Å)