7PAC
The crystal structure of PDE6D in the apo state
Summary for 7PAC
Entry DOI | 10.2210/pdb7pac/pdb |
Descriptor | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, NICKEL (II) ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, protein binding |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 19649.99 |
Authors | Beaumont, E.,Williams, D. (deposition date: 2021-07-29, release date: 2022-06-08, Last modification date: 2024-01-31) |
Primary citation | Canovas Nunes, S.,De Vita, S.,Anighoro, A.,Autelitano, F.,Beaumont, E.,Klingbeil, P.,McGuinness, M.,Duvert, B.,Harris, C.,Yang, L.,Pokharel, S.P.,Chen, C.W.,Ermann, M.,Williams, D.A.,Xu, H. Validation of a small molecule inhibitor of PDE6D-RAS interaction with favorable anti-leukemic effects. Blood Cancer J, 12:64-64, 2022 Cited by PubMed: 35422065DOI: 10.1038/s41408-022-00663-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
Download full validation report