7P85

Engineered phosphotriesterase BdPTE 10-2-C3(C59V/C227V) in complex with ethyl-4-methylbenzylphosphonate

Summary for 7P85

Entry DOI	10.2210/pdb7p85/pdb
Related	1PSC
Descriptor	Parathion hydrolase, ethyl-4-methylbenzylphosphonate, FORMIC ACID, ... (7 entities in total)
Functional Keywords	bioscavenger, enzyme engineering, organophosphate hydrolase, organophosphorous compound, phosphotriesterase, hydrolase
Biological source	Brevundimonas diminuta (Pseudomonas diminuta)
Total number of polymer chains	1
Total formula weight	38639.95
Authors	Eichinger, A.,Skerra, A. (deposition date: 2021-07-21, release date: 2022-08-03, Last modification date: 2024-02-07)
Primary citation	Job, L.,Kohler, A.,Eichinger, A.,Testanera, M.,Escher, B.,Worek, F.,Skerra, A. Structural and Functional Analysis of a Highly Active Designed Phosphotriesterase for the Detoxification of Organophosphate Nerve Agents Reveals an Unpredicted Conformation of the Active Site Loop. Biochemistry, 62:942-955, 2023 Cited by PubMed: 36752589 DOI: 10.1021/acs.biochem.2c00666 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.47 Å)

Structure validation