7P4F

Crystal Structure of Monoamine Oxidase B in complex with inhibitor 1

Summary for 7P4F

Entry DOI	10.2210/pdb7p4f/pdb
Descriptor	Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, 4-(hydroxymethyl)-7-[[4-[[methyl-(phenylmethyl)amino]methyl]phenyl]methoxy]chromen-2-one, ... (5 entities in total)
Functional Keywords	monoamine oxidase, drug target, neurodegeneration, mitochondrial membrane, flavoprotein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	120750.63
Authors	Iacovino, L.G.,Binda, C.,Pisani, L. (deposition date: 2021-07-11, release date: 2022-05-18, Last modification date: 2024-01-31)
Primary citation	Ekstrom, F.,Gottinger, A.,Forsgren, N.,Catto, M.,Iacovino, L.G.,Pisani, L.,Binda, C. Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures. Acs Med.Chem.Lett., 13:499-506, 2022 Cited by PubMed: 35300078 DOI: 10.1021/acsmedchemlett.2c00001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation