7P3I

Crystal structure of human CD40/TNFRSF5 in complex with the anti-CD40 DARPin protein

Summary for 7P3I

Entry DOI	10.2210/pdb7p3i/pdb
Descriptor	Tumor necrosis factor receptor superfamily member 5, Darpin, SODIUM ION, ... (4 entities in total)
Functional Keywords	tnfrsf5, immune-oncology, cd40, unknown function
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	72840.05
Authors	Malvezzi, F.,Mangold, S.,Hospodarsch, T.,Reichen, C.,Iss, C.,Lammens, A.,Krapp, S.,Domke, C. (deposition date: 2021-07-07, release date: 2022-04-06, Last modification date: 2022-05-11)
Primary citation	Rigamonti, N.,Veitonmaki, N.,Domke, C.,Barsin, S.,Jetzer, S.,Abdelmotaleb, O.,Bessey, R.,Lekishvili, T.,Malvezzi, F.,Gachechiladze, M.,Behe, M.,Levitsky, V.,Trail, P.A. A Multispecific Anti-CD40 DARPin Construct Induces Tumor-Selective CD40 Activation and Tumor Regression. Cancer Immunol Res, 10:626-640, 2022 Cited by PubMed: 35319751 DOI: 10.1158/2326-6066.CIR-21-0553 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.29 Å)

Structure validation