7P2B
Crystal structure of human gelsolin amyloid mutant A551P
Summary for 7P2B
Entry DOI | 10.2210/pdb7p2b/pdb |
Descriptor | Gelsolin, SULFATE ION, GLYCEROL, ... (5 entities in total) |
Functional Keywords | gelsolin protein, actin binding protein, structural protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 172532.10 |
Authors | Bollati, M.,de Rosa, M. (deposition date: 2021-07-05, release date: 2022-05-18, Last modification date: 2024-01-31) |
Primary citation | Bollati, M.,Diomede, L.,Giorgino, T.,Natale, C.,Fagnani, E.,Boniardi, I.,Barbiroli, A.,Alemani, R.,Beeg, M.,Gobbi, M.,Fakin, A.,Mastrangelo, E.,Milani, M.,Presciuttini, G.,Gabellieri, E.,Cioni, P.,de Rosa, M. A novel hotspot of gelsolin instability triggers an alternative mechanism of amyloid aggregation. Comput Struct Biotechnol J, 19:6355-6365, 2021 Cited by PubMed: 34938411DOI: 10.1016/j.csbj.2021.11.025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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