7P1M

Galectin-8 N-terminal carbohydrate recognition domain in complex with benzimidazole D-galactal ligand

Summary for 7P1M

Entry DOI	10.2210/pdb7p1m/pdb
Descriptor	Galectin-8, 2-[[(2R,3R,4R)-2-(hydroxymethyl)-3-oxidanyl-3,4-dihydro-2H-pyran-4-yl]oxymethyl]-3-methyl-benzimidazole-5-carboxylic acid, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	inhibitor, complex, galectin, lectin, d-galactal, sugar binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	34867.25
Authors	Hassan, M.,Hakansson, M.,Nilsson, J.U.,Kovacic, R. (deposition date: 2021-07-02, release date: 2021-12-15, Last modification date: 2024-01-31)
Primary citation	Hassan, M.,Baussiere, F.,Guzelj, S.,Sundin, A.P.,Hakansson, M.,Kovacic, R.,Leffler, H.,Tomasic, T.,Anderluh, M.,Jakopin, Z.,Nilsson, U.J. Structure-Guided Design of d-Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain. Acs Med.Chem.Lett., 12:1745-1752, 2021 Cited by PubMed: 34795863 DOI: 10.1021/acsmedchemlett.1c00371 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.52 Å)

Structure validation