7P11

Galectin-8 N-terminal carbohydrate recognition domain in complex with quinoline D-galactal ligand

Summary for 7P11

• Entry DOI: 10.2210/pdb7p11/pdb
• Descriptor: Isoform 2 of Galectin-8, Galectin-8, 2-[[(2~{R},3~{R},4~{R})-2-(hydroxymethyl)-3-oxidanyl-3,4-dihydro-2~{H}-pyran-4-yl]oxymethyl]quinoline-7-carboxylic acid, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, galectin, lectin, d-galactal, sugar binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 34747.13

Authors

Hassan, M.,Hakansson, M.,Nilsson, J.U.,Kovacic, R. (deposition date: 2021-07-01, release date: 2021-12-15, Last modification date: 2024-01-31)

• Primary citation: Hassan, M.,Baussiere, F.,Guzelj, S.,Sundin, A.P.,Hakansson, M.,Kovacic, R.,Leffler, H.,Tomasic, T.,Anderluh, M.,Jakopin, Z.,Nilsson, U.J.; Structure-Guided Design of d-Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain.; Acs Med.Chem.Lett., 12:1745-1752, 2021; PubMed: 34795863; DOI: 10.1021/acsmedchemlett.1c00371

Experimental method

X-RAY DIFFRACTION (2.1 Å)