7P0K

Crystal structure of Autotaxin (ENPP2) with 18F-labeled positron emission tomography ligand

This is a non-PDB format compatible entry.

Summary for 7P0K

• Entry DOI: 10.2210/pdb7p0k/pdb
• Descriptor: Isoform 2 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: autotaxin (atx), lysophosphatidic acid (lpa), fluorine-18, positron emission tomography (pet), inflammation, hydrolase
• Biological source: Rattus norvegicus (Norway rat)
• Total number of polymer chains: 1
• Total formula weight: 91604.14

Authors

Salgado-Polo, F.,Shao, T.,Xiao, Z.,Van, R.,Chen, J.,Rong, J.,Haider, A.,Shao, Y.,Josephson, L.,Perrakis, A.,Liang, S.H. (deposition date: 2021-06-29, release date: 2022-07-13, Last modification date: 2024-01-31)

• Primary citation: Deng, X.,Salgado-Polo, F.,Shao, T.,Xiao, Z.,Van, R.,Chen, J.,Rong, J.,Haider, A.,Shao, Y.,Josephson, L.,Perrakis, A.,Liang, S.H.; Imaging Autotaxin In Vivo with 18 F-Labeled Positron Emission Tomography Ligands; J Med Chem, 64:15053-15068, 2021; PubMed: 34662125; DOI: 10.1021/acs.jmedchem.1c00913

Experimental method

X-RAY DIFFRACTION (2.2 Å)