7OWG

human DEPTOR in a complex with mutant human mTORC1 A1459P

Summary for 7OWG

• Entry DOI: 10.2210/pdb7owg/pdb
• EMDB information: 13097
• Descriptor: Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, DEP domain-containing mTOR-interacting protein, ... (4 entities in total)
• Functional Keywords: kinase, pikk, mtor, cancer-associated mutation, deptor, partial inhibitor, cancer, pdz, non-canonical pdz binding, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 519046.25

Authors

Heimhalt, M.,Berndt, A.,Wagstaff, J.,Anandapadamanaban, M.,Perisic, O.,Maslen, S.,McLaughlin, S.,Yu, W.-H.,Masson, G.R.,Boland, A.,Ni, X.,Yamashita, K.,Murshudov, G.N.,Skehel, M.,Freund, S.M.,Williams, R.L. (deposition date: 2021-06-18, release date: 2021-09-08, Last modification date: 2022-02-23)

• Primary citation: Heimhalt, M.,Berndt, A.,Wagstaff, J.,Anandapadamanaban, M.,Perisic, O.,Maslen, S.,McLaughlin, S.,Yu, C.W.,Masson, G.R.,Boland, A.,Ni, X.,Yamashita, K.,Murshudov, G.N.,Skehel, M.,Freund, S.M.,Williams, R.L.; Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace.; Elife, 10:-, 2021; PubMed: 34519269; DOI: 10.7554/eLife.68799

Experimental method

ELECTRON MICROSCOPY (4.7 Å)