7OUF

Structure of the STLV intasome:B56 complex bound to the strand-transfer inhibitor XZ450

Summary for 7OUF

• Entry DOI: 10.2210/pdb7ouf/pdb
• EMDB information: 13075
• Descriptor: Integrase, Isoform 3 of PC4 and SFRS1-interacting protein,Isoform Gamma-1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, DNA (5'-D(*AP*CP*TP*GP*TP*GP*TP*TP*TP*GP*GP*CP*GP*CP*TP*TP*CP*TP*CP*TP*C)-3'), ... (8 entities in total)
• Functional Keywords: stlv-1 intasome, integrase strand-transfer inhibitor, htlv, raltegravir, viral protein
• Biological source: Simian T-lymphotropic virus 1; More
• Total number of polymer chains: 10
• Total formula weight: 333444.15

Authors

Barski, M.S.,Ballandras-Colas, A.,Cronin, N.B.,Pye, V.E.,Cherepanov, P.,Maertens, G.N. (deposition date: 2021-06-11, release date: 2021-08-18, Last modification date: 2021-10-06)

• Primary citation: Barski, M.S.,Vanzo, T.,Zhao, X.Z.,Smith, S.J.,Ballandras-Colas, A.,Cronin, N.B.,Pye, V.E.,Hughes, S.H.,Burke Jr., T.R.,Cherepanov, P.,Maertens, G.N.; Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures.; Nat Commun, 12:4996-4996, 2021; PubMed: 34404793; DOI: 10.1038/s41467-021-25284-1

Experimental method

ELECTRON MICROSCOPY (3 Å)