7OU8

Human O-GlcNAc hydrolase in complex with DNJNAc-thiazolidines

This is a non-PDB format compatible entry.

Summary for 7OU8

• Entry DOI: 10.2210/pdb7ou8/pdb
• Related: 7OU6
• Descriptor: O-GlcNAcase BT_4395, ~{N}-[(3~{Z},6~{S},7~{R},8~{R},8~{a}~{S})-7,8-bis(oxidanyl)-3-(phenylmethyl)imino-1,5,6,7,8,8~{a}-hexahydro-[1,3]thiazolo[3,4-a]pyridin-6-yl]ethanamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: carbohydrate, inhibitor, probe, n-acetylglucosamine, hydrolase
• Biological source: Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
• Total number of polymer chains: 2
• Total formula weight: 169948.83

Authors

Males, A.,Davies, G.J.,Gonzalez-Cuesta, M.,Mellet, C.O.,Fernandez, J.M.G.,Sidhu, P.,Ashmus, R.,Busmann, J.,Vocadlo, D.J.,Foster, L. (deposition date: 2021-06-11, release date: 2022-04-13, Last modification date: 2024-01-31)

• Primary citation: Gonzalez-Cuesta, M.,Sidhu, P.,Ashmus, R.A.,Males, A.,Proceviat, C.,Madden, Z.,Rogalski, J.C.,Busmann, J.A.,Foster, L.J.,Garcia Fernandez, J.M.,Davies, G.J.,Ortiz Mellet, C.,Vocadlo, D.J.; Bicyclic Picomolar OGA Inhibitors Enable Chemoproteomic Mapping of Its Endogenous Post-translational Modifications; J.Am.Chem.Soc., 144:832-844, 2022; DOI: 10.1021/jacs.1c10504

Experimental method

X-RAY DIFFRACTION (1.5 Å)