7ORF

Crystal structure of JNK3 in complex with FMU-001-367 (compound 1)

Summary for 7ORF

Entry DOI	10.2210/pdb7orf/pdb
Descriptor	Mitogen-activated protein kinase 10, N-[4-[[4-[5-(4-fluorophenyl)-3-methyl-2-methylsulfanyl-imidazol-4-yl]pyridin-2-yl]amino]phenyl]-3-(propanoylamino)benzamide, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	kinase, mapk, mapk10, light activation, covalent inhibitor, structural genomics, structural genomics consortium, sgc, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	44164.02
Authors	Chaikuad, A.,Koch, P.,Laufer, S.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2021-06-05, release date: 2021-07-21, Last modification date: 2024-01-31)
Primary citation	Reynders, M.,Chaikuad, A.,Berger, B.T.,Bauer, K.,Koch, P.,Laufer, S.,Knapp, S.,Trauner, D. Controlling the Covalent Reactivity of a Kinase Inhibitor with Light. Angew.Chem.Int.Ed.Engl., 60:20178-20183, 2021 Cited by PubMed: 34081840 DOI: 10.1002/anie.202103767 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation