7OOW

Crystal structure of PIM1 in complex with ARC-1415

Summary for 7OOW

Entry DOI	10.2210/pdb7oow/pdb
Related PRD ID	PRD_002339 PRD_002350
Descriptor	Serine/threonine-protein kinase pim-1, INHIBITOR ARC-1415, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	pim1, inhibitor, kinase, kinase substrate, structural genomics, structural genomics consortium, sgc, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	37177.70
Authors	Chaikuad, A.,Dixon-Clarke, S.E.,Nonga, O.E.,Uri, A.,Bullock, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2021-05-28, release date: 2021-08-04, Last modification date: 2024-04-10)
Primary citation	Nonga, O.E.,Lavogina, D.,Enkvist, E.,Kestav, K.,Chaikuad, A.,Dixon-Clarke, S.E.,Bullock, A.N.,Kopanchuk, S.,Ivan, T.,Ekambaram, R.,Viht, K.,Knapp, S.,Uri, A. Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family. Molecules, 26:-, 2021 Cited by PubMed: 34299628 DOI: 10.3390/molecules26144353 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation