7OIL

mPI3Kd in complex with compound 58

This is a non-PDB format compatible entry.

Summary for 7OIL

• Entry DOI: 10.2210/pdb7oil/pdb
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, SODIUM ION, 2-[(1S)-1-cyclopropylethyl]-5-[4-methyl-2-[[6-(2-oxidanylidenepyrrolidin-1-yl)pyridin-2-yl]amino]-1,3-thiazol-5-yl]-7-methylsulfonyl-3H-isoindol-1-one, ... (4 entities in total)
• Functional Keywords: mpi3kd, inhibitor, complex, transferase
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 1
• Total formula weight: 125409.19

Authors

Petersen, J. (deposition date: 2021-05-11, release date: 2021-07-14, Last modification date: 2021-09-29)

• Primary citation: Perry, M.W.D.,Bjorhall, K.,Bold, P.,Brulls, M.,Borjesson, U.,Carlsson, J.,Chang, H.A.,Chen, Y.,Eriksson, A.,Fihn, B.M.,Fransson, R.,Fredlund, L.,Ge, H.,Huang, H.,Karabelas, K.,Lamm Bergstrom, E.,Lever, S.,Lindmark, H.,Mogemark, M.,Nikitidis, A.,Palmgren, A.P.,Pemberton, N.,Petersen, J.,Rodrigo Blomqvist, M.,Smith, R.W.,Thomas, M.J.,Ullah, V.,Tyrchan, C.,Wennberg, T.,Westin Eriksson, A.,Yang, W.,Zhao, S.,Oster, L.; Discovery of AZD8154, a Dual PI3K gamma delta Inhibitor for the Treatment of Asthma.; J.Med.Chem., 64:8053-8075, 2021; PubMed: 34080862; DOI: 10.1021/acs.jmedchem.1c00434

Experimental method

X-RAY DIFFRACTION (1.95 Å)