7OIJ

mPI3Kd in complex with an inhibitor

This is a non-PDB format compatible entry.

Summary for 7OIJ

• Entry DOI: 10.2210/pdb7oij/pdb
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, 6-[[5-[2-[(1S)-1-cyclopropylethyl]-7-(methylsulfamoyl)-1-oxidanylidene-3H-isoindol-5-yl]-4-methyl-1,3-thiazol-2-yl]amino]-N-[3-(dimethylamino)propyl]pyridine-2-carboxamide, SODIUM ION, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, transferase
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 1
• Total formula weight: 125619.46

Authors

Petersen, J. (deposition date: 2021-05-11, release date: 2021-07-14, Last modification date: 2021-09-29)

• Primary citation: Perry, M.W.D.,Bjorhall, K.,Bold, P.,Brulls, M.,Borjesson, U.,Carlsson, J.,Chang, H.A.,Chen, Y.,Eriksson, A.,Fihn, B.M.,Fransson, R.,Fredlund, L.,Ge, H.,Huang, H.,Karabelas, K.,Lamm Bergstrom, E.,Lever, S.,Lindmark, H.,Mogemark, M.,Nikitidis, A.,Palmgren, A.P.,Pemberton, N.,Petersen, J.,Rodrigo Blomqvist, M.,Smith, R.W.,Thomas, M.J.,Ullah, V.,Tyrchan, C.,Wennberg, T.,Westin Eriksson, A.,Yang, W.,Zhao, S.,Oster, L.; Discovery of AZD8154, a Dual PI3K gamma delta Inhibitor for the Treatment of Asthma.; J.Med.Chem., 64:8053-8075, 2021; PubMed: 34080862; DOI: 10.1021/acs.jmedchem.1c00434

Experimental method

X-RAY DIFFRACTION (1.8 Å)