7OAK

Crystal structure of pseudokinase CASK in complex with compound 26

Summary for 7OAK

• Entry DOI: 10.2210/pdb7oak/pdb
• Descriptor: Peripheral plasma membrane protein CASK, 2-[[2,5-bis(bromanyl)-4-methyl-phenyl]methylamino]-4-(cyclopentylamino)-N-[3-(2-oxidanylidene-1,3-oxazolidin-3-yl)propyl]pyrimidine-5-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: pseudokinase, kinase, inhibitor, structural genomics, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 161704.50

Authors

Chaikuad, A.,Russ, N.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2021-04-19, release date: 2021-05-19, Last modification date: 2024-01-31)

• Primary citation: Russ, N.,Schroder, M.,Berger, B.T.,Mandel, S.,Aydogan, Y.,Mauer, S.,Pohl, C.,Drewry, D.H.,Chaikuad, A.,Muller, S.,Knapp, S.; Design and Development of a Chemical Probe for Pseudokinase Ca 2+ /calmodulin-Dependent Ser/Thr Kinase.; J.Med.Chem., 64:14358-14376, 2021; PubMed: 34543009; DOI: 10.1021/acs.jmedchem.1c00845

Experimental method

X-RAY DIFFRACTION (2.23 Å)