7NZH

Crystal structure of HLA-DR4 in complex with a citrullinated cilp peptide

This is a non-PDB format compatible entry.

Summary for 7NZH

• Entry DOI: 10.2210/pdb7nzh/pdb
• Descriptor: HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DR beta chain, citrullinated cartilage intermediate layer protein (CILP) peptide 982-996, ... (5 entities in total)
• Functional Keywords: complex, mhcii, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 91154.77

Authors

Ge, C.,Holmdahl, R. (deposition date: 2021-03-24, release date: 2022-05-11, Last modification date: 2024-01-31)

• Primary citation: Ge, C.,Weisse, S.,Xu, B.,Dobritzsch, D.,Viljanen, J.,Kihlberg, J.,Do, N.N.,Schneider, N.,Lanig, H.,Holmdahl, R.,Burkhardt, H.; Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor.; Ann Rheum Dis, 81:480-489, 2022; PubMed: 35027402; DOI: 10.1136/annrheumdis-2021-220500

Experimental method

X-RAY DIFFRACTION (2.831 Å)