7NWV
Structure of recombinant human beta-glucocerebrosidase in complex with BODIPY Tagged Cyclophellitol activity based probe
This is a non-PDB format compatible entry.
Summary for 7NWV
Entry DOI | 10.2210/pdb7nwv/pdb |
Descriptor | Lysosomal acid glucosylceramidase, 1-deoxy-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (8 entities in total) |
Functional Keywords | beta-glucocerebrosidase, lysosomal glycoside hydrolase, gh30, hydrolase, cyclophellitol epoxide, activity based probe, complex |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 117526.12 |
Authors | Rowland, R.J.,Davies, G.J. (deposition date: 2021-03-17, release date: 2022-03-30, Last modification date: 2024-01-31) |
Primary citation | van der Gracht, D.,Rowland, R.J.,Roig-Zamboni, V.,Ferraz, M.J.,Louwerse, M.,Geurink, P.P.,Aerts, J.M.F.G.,Sulzenbacher, G.,Davies, G.J.,Overkleeft, H.S.,Artola, M. Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases. Chem Sci, 14:9136-9144, 2023 Cited by PubMed: 37655021DOI: 10.1039/d3sc01021j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.86 Å) |
Structure validation
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