7NKZ

Cryo-EM structure of the cytochrome bd oxidase from M. tuberculosis at 2.5 A resolution

Summary for 7NKZ

• Entry DOI: 10.2210/pdb7nkz/pdb
• EMDB information: 12451
• Descriptor: Probable integral membrane cytochrome D ubiquinol oxidase (Subunit II) CydB (Cytochrome BD-I oxidase subunit II), Probable integral membrane cytochrome D ubiquinol oxidase (Subunit I) CydA (Cytochrome BD-I oxidase subunit I), OXYGEN MOLECULE, ... (7 entities in total)
• Functional Keywords: terminal oxidase oxidoreductase oxygen reductase bd oxidase, membrane protein
• Biological source: Mycobacterium tuberculosis H37Rv; More
• Total number of polymer chains: 2
• Total formula weight: 94200.78

Authors

Safarian, S.,Wu, D.,Krause, K.L.,Michel, H. (deposition date: 2021-02-19, release date: 2021-09-22, Last modification date: 2021-09-29)

• Primary citation: Safarian, S.,Opel-Reading, H.K.,Wu, D.,Mehdipour, A.R.,Hards, K.,Harold, L.K.,Radloff, M.,Stewart, I.,Welsch, S.,Hummer, G.,Cook, G.M.,Krause, K.L.,Michel, H.; The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB.; Nat Commun, 12:5236-5236, 2021; PubMed: 34475399; DOI: 10.1038/s41467-021-25537-z

Experimental method

ELECTRON MICROSCOPY (2.5 Å)