7NEE

Inhibitor Complex with Thrombin Activatable Fibrinolysis inhibitor (TAFIa)

Summary for 7NEE

Entry DOI	10.2210/pdb7nee/pdb
Descriptor	Carboxypeptidase B2, (1R,3S)-3-(4-ammoniobutyl)-1-benzyl-1,4-azaphosphinan-1-ium-3-carboxylate 4,4-dioxide, ZINC ION, ... (4 entities in total)
Functional Keywords	inhibitor, complex, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	46340.78
Authors	Brown, D.G.,Schaffner, A.P.,Gloanec, P.,Raimbaud, E.,Vuillard, L.M. (deposition date: 2021-02-03, release date: 2021-04-07, Last modification date: 2024-05-01)
Primary citation	Schaffner, A.P.,Sansilvestri-Morel, P.,Despaux, N.,Ruano, E.,Persigand, T.,Rupin, A.,Mennecier, P.,Vallez, M.O.,Raimbaud, E.,Desos, P.,Gloanec, P. Phosphinanes and Azaphosphinanes as Potent and Selective Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor (TAFIa). J.Med.Chem., 64:3897-3910, 2021 Cited by PubMed: 33764059 DOI: 10.1021/acs.jmedchem.0c02072 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation