7MRZ
Structure of GDF11 bound to fused ActRIIB-ECD and Alk4-ECD with Anti-ActRIIB Fab fragment
Summary for 7MRZ
Entry DOI | 10.2210/pdb7mrz/pdb |
Descriptor | Growth/differentiation factor 11, Activin receptor type-2B,Activin receptor type-1B, Fab Heavy Chain, ... (6 entities in total) |
Functional Keywords | growth factor, type i receptor, transforming growth factor beta, type ii receptor, ternary complex, gdf11, signaling protein, signaling protein-immune system complex, signaling protein/immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 88371.92 |
Authors | Goebel, E.J.,Kattamuri, C.,Gipson, G.R.,Thompson, T.B. (deposition date: 2021-05-10, release date: 2022-01-19, Last modification date: 2023-10-18) |
Primary citation | Goebel, E.J.,Kattamuri, C.,Gipson, G.R.,Krishnan, L.,Chavez, M.,Czepnik, M.,Maguire, M.C.,Grenha, R.,Hakansson, M.,Logan, D.T.,Grinberg, A.V.,Sako, D.,Castonguay, R.,Kumar, R.,Thompson, T.B. Structures of activin ligand traps using natural sets of type I and type II TGF beta receptors. Iscience, 25:103590-103590, 2022 Cited by PubMed: 35005539DOI: 10.1016/j.isci.2021.103590 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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