7MR7
Crystal structure of the first bromodomain (BD1) of human BRD4 bound to GXH-II-075
Summary for 7MR7
Entry DOI | 10.2210/pdb7mr7/pdb |
Descriptor | Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 4-[(4-{4-chloro-3-[(2-methylpropane-2-sulfonyl)amino]anilino}-5-methylpyrimidin-2-yl)amino]-2-fluoro-N-[1-(14-{3-[(2-{3-fluoro-4-[(piperidin-4-yl)carbamoyl]anilino}-5-methylpyrimidin-4-yl)amino]-5-[(2-methylpropane-2-sulfonyl)amino]phenyl}-14-oxo-4,7,10-trioxa-13-azatetradecanan-1-oyl)piperidin-4-yl]benzamide, ... (4 entities in total) |
Functional Keywords | bromosporine, brd4, brd, bet, gene regulation |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 31759.97 |
Authors | Chan, A.,Schonbrunn, E. (deposition date: 2021-05-07, release date: 2022-05-11, Last modification date: 2023-10-18) |
Primary citation | Guan, X.,Cheryala, N.,Karim, R.M.,Chan, A.,Berndt, N.,Qi, J.,Georg, G.I.,Schonbrunn, E. Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity. J.Med.Chem., 65:10441-10458, 2022 Cited by PubMed: 35867655DOI: 10.1021/acs.jmedchem.2c00453 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
Download full validation report