7MOH
Crystal Structure of Arabidopsis thaliana Plant and Fungi Atypical Dual Specificity Phosphatase 1(AtPFA-DSP1 ) Cys150Ser in complex with 5-diphosphoinositol 1,3,4,6-tetrakisphosphate (5PP-InsP4) and phosphate in conformation B (Pi(B))
Summary for 7MOH
Entry DOI | 10.2210/pdb7moh/pdb |
Descriptor | Tyrosine-protein phosphatase DSP1, (1r,2R,3S,4r,5R,6S)-4-hydroxy-2,3,5,6-tetrakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | inositol, inositol pyrophosphate, transferase, hydrolase, cell-signaling, phosphatase, substrate recognition, reaction mechanism, intermediate, phosphate, metaphosphate, molecular dynamic simulation, self-activation, catalytic water |
Biological source | Arabidopsis thaliana (Mouse-ear cress) |
Total number of polymer chains | 2 |
Total formula weight | 40700.58 |
Authors | Wang, H.,Shears, S.B. (deposition date: 2021-05-01, release date: 2022-03-02, Last modification date: 2024-05-22) |
Primary citation | Wang, H.,Perera, L.,Jork, N.,Zong, G.,Riley, A.M.,Potter, B.V.L.,Jessen, H.J.,Shears, S.B. A structural expose of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop. Nat Commun, 13:2231-2231, 2022 Cited by PubMed: 35468885DOI: 10.1038/s41467-022-29673-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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