7MOF

Crystal Structure of Arabidopsis thaliana Plant and Fungi Atypical Dual Specificity Phosphatase 1(AtPFA-DSP1 ) Cys150Ser in complex with 6-diphosphoinositol 1,2,3,4,5-pentakisphosphate 6-InsP7

Summary for 7MOF

• Entry DOI: 10.2210/pdb7mof/pdb
• Descriptor: Tyrosine-protein phosphatase DSP1, (1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, INOSITOL HEXAKISPHOSPHATE, ... (4 entities in total)
• Functional Keywords: inositol, inositol pyrophosphate, transferase, hydrolase, cell-signaling, phosphatase, substrate recognition, reaction mechanism, intermediate, phosphate, metaphosphate, molecular dynamic simulation, self-activation, catalytic water
• Biological source: Arabidopsis thaliana (Mouse-ear cress)
• Total number of polymer chains: 2
• Total formula weight: 41425.61

Authors

Wang, H.,Shears, S.B. (deposition date: 2021-05-01, release date: 2022-03-02, Last modification date: 2022-05-11)

• Primary citation: Wang, H.,Perera, L.,Jork, N.,Zong, G.,Riley, A.M.,Potter, B.V.L.,Jessen, H.J.,Shears, S.B.; A structural expose of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop.; Nat Commun, 13:2231-2231, 2022; PubMed: 35468885; DOI: 10.1038/s41467-022-29673-y

Experimental method

X-RAY DIFFRACTION (1.95 Å)