7MIH

Human CTPS2 bound to inhibitor R80

Summary for 7MIH

Entry DOI	10.2210/pdb7mih/pdb
EMDB information	23851
Descriptor	CTP synthase 2, N-(1-{2-[(cyclopropanesulfonyl)amino]-1,3-thiazol-4-yl}cyclopropyl)-5-(6-ethoxypyrazin-2-yl)pyridine-2-carboxamide, URIDINE 5'-TRIPHOSPHATE, ... (5 entities in total)
Functional Keywords	glutaminase, amidoligase, nucleotide metabolism, ligase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	267602.35
Authors	Lynch, E.M.,Dimattia, M.A.,Kollman, J.M. (deposition date: 2021-04-16, release date: 2021-10-13, Last modification date: 2024-05-29)
Primary citation	Lynch, E.M.,DiMattia, M.A.,Albanese, S.,van Zundert, G.C.P.,Hansen, J.M.,Quispe, J.D.,Kennedy, M.A.,Verras, A.,Borrelli, K.,Toms, A.V.,Kaila, N.,Kreutter, K.D.,McElwee, J.J.,Kollman, J.M. Structural basis for isoform-specific inhibition of human CTPS1. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 34583994 DOI: 10.1073/pnas.2107968118 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.8 Å)

Structure validation