7MHC

Structure of human STING in complex with MK-1454

Summary for 7MHC

• Entry DOI: 10.2210/pdb7mhc/pdb
• Descriptor: Stimulator of interferon genes protein, (2R,5R,7R,8S,10R,12aR,14R,15S,15aR,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-15,16-difluoro-2,10-bis(sulfanyl)octahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione (3 entities in total)
• Functional Keywords: sting, receptor, ligand complex, agonist, closed conformation, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 22263.70

Authors

Lesburg, C.A. (deposition date: 2021-04-15, release date: 2022-04-06, Last modification date: 2023-10-18)

• Primary citation: McIntosh, J.A.,Liu, Z.,Andresen, B.M.,Marzijarani, N.S.,Moore, J.C.,Marshall, N.M.,Borra-Garske, M.,Obligacion, J.V.,Fier, P.S.,Peng, F.,Forstater, J.H.,Winston, M.S.,An, C.,Chang, W.,Lim, J.,Huffman, M.A.,Miller, S.P.,Tsay, F.R.,Altman, M.D.,Lesburg, C.A.,Steinhuebel, D.,Trotter, B.W.,Cumming, J.N.,Northrup, A.,Bu, X.,Mann, B.F.,Biba, M.,Hiraga, K.,Murphy, G.S.,Kolev, J.N.,Makarewicz, A.,Pan, W.,Farasat, I.,Bade, R.S.,Stone, K.,Duan, D.,Alvizo, O.,Adpressa, D.,Guetschow, E.,Hoyt, E.,Regalado, E.L.,Castro, S.,Rivera, N.,Smith, J.P.,Wang, F.,Crespo, A.,Verma, D.,Axnanda, S.,Dance, Z.E.X.,Devine, P.N.,Tschaen, D.,Canada, K.A.,Bulger, P.G.,Sherry, B.D.,Truppo, M.D.,Ruck, R.T.,Campeau, L.C.,Bennett, D.J.,Humphrey, G.R.,Campos, K.R.,Maddess, M.L.; A kinase-cGAS cascade to synthesize a therapeutic STING activator.; Nature, 603:439-444, 2022; PubMed: 35296845; DOI: 10.1038/s41586-022-04422-9

Experimental method

X-RAY DIFFRACTION (2.32 Å)